2015 Fiscal Year Final Research Report
Impact of inflammation-metaplasia-adenocarcinoma sequence and inflammatory microenvironment in esophageal carcinogenesis using surgical rat models
| Project/Area Number |
25462016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Ohta Tetsuo 金沢大学, 医学系, 教授 (40194170)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 食道発癌 / 逆流性食道炎 / 腫瘍微小環境 |
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| Outline of Final Research Achievements |
Macrophages infiltrate the esophagus and activate the pStat3 pathway in stromal cells and epithelium. M2 phenotype macrophages infiltrate following infiltration of M1 macrophage and contribute to tumor development through regulatory T cells (Tregs). The involvement of immune cells such as TAMs and Tregs in the inflammatory microenvironment promotes esophageal carcinogenesis.
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| Free Research Field |
消化器外科
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