Therapeutic aplication to gastric cancer by CD24 expression control

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462023
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hiroshima University
• Principal Investigator: TANABE Kazuaki 広島大学, 医歯薬保健学研究院(医), 准教授 (40379847)
• Co-Investigator(Kenkyū-buntansha): 徳本 憲昭 広島大学, 大学病院, 病院助教 (90564980)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胃癌 / CD24 / 低酸素

Outline of Final Research Achievements

We investigated the involvement of CD24 in gastric cancer aggressiveness. Purely sorted CD24-negative gastric cancer cells showed strong alteration into the CD24-positive cell type, and reached to steady expression levels. Our clinicopathological study revealed that CD24 positivity was an independent prognostic factor of gastric cancer. CD24 expression was correlated with the advanced stages, invasiveness, and lymph node metastasis of gastric cancer. Silencing of CD24 in cultured cells significantly decreased cell migration and invasion. Hypoxic treatment upregulated CD24 expression, and simultaneously induced cell motility and invasion of gastric cancer cells. Hypoxic treatmentinduced CD24 expression was significantly attenuated by knockdown of hypoxiainducible transcription factors. CD24 would be an attractive marker to define not only the heterogeneity but also the aggressiveness of gastric cancer cells.

Free Research Field

上部消化管外科の臨床・研究