2015 Fiscal Year Final Research Report
Function analysis of SPINK1 in normal gastric mucosa epithelium and gastric cancer
Project/Area Number |
25462029
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Kumamoto University |
Principal Investigator |
OZAKI Nobuyuki 熊本大学, 医学部附属病院, 非常勤診療医師 (40551255)
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Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Daisuke 熊本大学, 医学部附属病院, 助教 (80508507)
ISHIMOTO Takatsugu 熊本大学, 国際先端医学研究拠点, 客員准教授 (00594889)
Ohmuraya Masaki 熊本大学, 生命資源開発センター, 准教授 (60398229)
WATANABE Masayuki 公益財団法人がん研究会, がん研有明病院, 食道担当部長 (80254639)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 膵分泌性トリプシンインヒビター / 正常胃粘膜 / 胃癌 |
Outline of Final Research Achievements |
We analyzed an expression system of SPINK1 of normal gastric mucosa epithelium and analyzed it in gastric cancer at the same time. SPINK1 expressed to a gastric mucosa cell and worked in protection of gastric mucosa and vulnerary acceleration of ulcer locus. It was particularly strongly confirmed expression in crypt in a stomach and expressed to the cell which had a property of stem cell. We particularly strongly expressed in well differentiated type in gastric cancer, and did not recognize most expression about undifferentiated carcinoma.
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Free Research Field |
消化器外科学
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