Predictive Markers of the Effect of Chemoradiotherapy in Rectal Cancer Patients

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462074
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: National Defense Medical College
• Principal Investigator: Shinto Eiji 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師 (30626619)
• Co-Investigator(Kenkyū-buntansha): HASE Kazuo 防衛医科大学校, 医学教育部医学科専門課程, 教授 (50511268) ; UENO Hideki 防衛医科大学校, 医学教育部医学科専門課程, 准教授 (90597535) ; HAYASHI Katsumi 防衛医科大学校, 病院, 講師 (10532517) ; KAJI Tatsumi 防衛医科大学校, 病院, 教授 (50148110)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 直腸癌 / 術前化学放射線療法

Outline of Final Research Achievements

Preoperative chemoradiotherapy (CRT) can cause tumor regression, which has been associated with increased postoperative local control. However, CRT results in some toxicities and complications, thus the prediction of tumor response is essential for tailoring treatments to individual patients. We obtained pretreatment biopsy specimens and investigated if the grade of CD8+ tumor-infiltrating lymphocytes, expression of CD133, COX-2 or cancer stem cell markers can be used as predictive markers, prospectively and retrospectively. Finally, our retrospective study revealed the predictive values of 3 indicators (CD8/CD133/COX-2) in histological tumor regression after preoperative CRT, and we succeeded in the validation study through a prospective study. Additionally, we disclosed that cancer stem cell marker expressions were associated with poor prognosis after CRT.

Free Research Field

消化器外科