Liver repair mediated by lipid mediators

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462100
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kitasato University
• Principal Investigator: ITO YOSHIYA 北里大学, 医学部, 非常勤講師 (40203187)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脂質メディエーター / 肝修復 / マクロファージ

Outline of Final Research Achievements

Liver injury elicited by ischemia and reperfusion is an important clinical problem after liver resection or transplantation, because the failure of liver to regenerate is considered a critical contributing factor in liver dysfunction and liver failure after liver surgery.　The present study was conducted to examine whether or not leukotriene B4 (LTB4) and its receptor BLT1 are involved in liver repair and regeneration following hepatic ischemia/reperfusion in mice. BLT1 signaling facilitates liver repair during hepatic ischemia/reperfusion through production of epidermal growth factor in recruited macrophages in injured lesion. LTB4/BLT1 signaling pathway plays a critical role in liver repair after acute liver injury.

Free Research Field

消化器外科