The improvement of therapy-resistance with modified new virus and application to the treatment in pancreatic cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: EGAMI Takuya 九州大学, 医学(系)研究科(研究院), 共同研究員 (40507787)
• Co-Investigator(Kenkyū-buntansha): MIZUMOTO Kazuhiro 九州大学, 大学病院, 准教授 (90253418) ; NAKATA Kohei 九州大学, 大学病院, 特別教員 (30419569)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膵癌 / 治療耐性 / ウイルス

Outline of Final Research Achievements

We investigated the factors which were involved in the radioresistance and anticancer drug resistance in pancreatic cancer in order to create a foundation for modifying the new viral vectors.
First, we found that S100A4 mRNA expression may predict radioresistance of pancreatic cancer cells and may play an important role in the poor response of pancreatic cancer cells to radiation therapy. Furthermore, we found that the antifibrotic agent, pirfenidone could be promising agents targeting desmoplasia by suppression of PSCs and production of growth factors and stromal components related to tumor-stromal interactions.

Free Research Field

医歯薬学