2015 Fiscal Year Final Research Report
Elucidation of the mechanism of transplanted rejected airways with special reference to innate immunity
| Project/Area Number |
25462173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA JUN 東京大学, 医学部附属病院, 教授 (90188954)
NAGAYAMA KAZUHIRO 東京大学, 医学部附属病院, 助教 (00647935)
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| Research Collaborator |
MURAYAMA TOMONORI 東京大学, 医学部附属病院
KAWASHIMA MITSUAKI 東京大学, 医学部附属病院
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 肺移植 / 閉塞性細気管支炎 / 自然免疫 |
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| Outline of Final Research Achievements |
We confirmed that allograft airway fibrosis was reduced in toll-like receptor 4 (TLR4) mutant recipient mouse. This result suggests that not only acquired immunity but also innate immunity including TLR4 signal transduction control allo-immune response and tissue remodeling. In future perspective, using TLR4 inhibitor may be an innovative therapeutic option to reduce allograft airway fibrosis that cannot be inhibited by already established immune-suppressants.
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| Free Research Field |
胸部外科学
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