Immunoescape from innnate/adoptive antitumor immunity via EGF family receptor in non-small cell lung cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462189
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kawasaki Medical School
• Principal Investigator: Okita Riki 川崎医科大学, 医学部, 講師 (90467762)
• Co-Investigator(Kenkyū-buntansha): NAKATA Masao 川崎医科大学, 医学部, 教授 (30368641)
• Research Collaborator: Kiessling Rolf カロリンスカ研究所, 教授
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腫瘍免疫 / 非小細胞肺癌 / 悪性胸膜中皮腫 / NK細胞 / EGFR / HER2 / NKG2Dリガンド / NK細胞傷害活性

Outline of Final Research Achievements

We reported following findings. 1: EGFR/PI3K-AKT signaling regulates the expression of NKG2D ligands MICB via miR20a, resulted in enhanced NK cell-mediated cytotoxicity against non-small cell lung cancer cells. 2: Overexpression of MICA/B is independent improved prognostic factor for patients with non-small cell lung cancer. 3: EGFR/HER2 dual tyrosine kinase inhibitor lapatinib upregulates HER2, resulted in enhanced antibody dependent cellular cytotoxicity with NK cells in malignant mesothelioma cell lines.

Free Research Field

腫瘍外科学