Experimental creation of giant cerebral aneurysm and development its therapeutic strategy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462207
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Yoshino Yoshikazu 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (70323681)
• Co-Investigator(Renkei-kenkyūsha): NEMOTO Shigeru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20228290) ; MIKI Kazunori 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (00536823) ; TOMORI Toshiki 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (50634127)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脳動脈瘤 / 巨大脳動脈瘤 / 血管内治療

Outline of Final Research Achievements

We analyzed the factors that related to the increase in the size of the cerebral aneurysm and the formation of intra-aneurysmal thrombosis using the technique of computed fluid dynamics (CFD) and computer aided design (CAD) techniques. Then we verified the results of these factors by the well controlled animal experiments of giant aneurysm model. Although there are some factors suggested to be related to the increase in size of cerebral aneurysm, such as the blood velocity at the neck of aneurysm or the wideness of the aneurysm base, this study could not clarify the significant factor that related to the extensive growth of the aneurysms in the animal experiments. By applying the current research results to the real clinical practice, it is expected that the outcome of the treatment for large or giant cerebral aneurysm will improve.

Free Research Field

脳神経外科