2016 Fiscal Year Final Research Report
Development of novel therapy based on functional reorganization in brain tumor patients
| Project/Area Number |
25462247
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUZAWA Hitoshi 新潟大学, 脳研究所, 准教授 (70303170)
HIRAISHI Tetsuya 新潟大学, 脳研究所, 助教 (80515734)
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| Research Collaborator |
AOKI Hiroshi
KURABE Satoshi
TSUKAMOTO Yoshihiro
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 脳腫瘍 / 脳機能再構築 / fMRI / NIRS / 新規治療 |
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| Outline of Final Research Achievements |
Motor functions in brain tumor patients were assessed by fMRI. The locus of primary sensory motor activation during contralesional hand grasp was displaced by the tumor, suggesting functional compromise and/or reorganization in the central sulcus region. Their contralesional cerebellum activation during contralesional hand grasp was also increased as compared to normal subjects, representing the first evidence that the cerebellum is involved in the functional reorganization in brain tumor patients.
Intraoperative language functions were studied using NIRS. Cortical stimulation of Broca’s area elicits hemodynamic responses of NIRS in Wernicke’s area via cortico-cortical connectivity, demonstrating visualization of cortico-cortical evoked responses in language systems.
These results can contribute to understand the mechanism for functional reorganization in brain tumor patients and provide important information on developing new therapy for brain tumors based on reorganization.
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| Free Research Field |
脳神経外科学
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