Radiation therapy for functional neuronal disorders: application of selective neuronal death using microbeam X-ray

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462259
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kobe University
• Principal Investigator: Kondoh Takeshi 神戸大学, 医学(系)研究科(研究院), 研究員 (50273769)
• Co-Investigator(Kenkyū-buntansha): Mizukawa Katsu 神戸大学, 医学部附属病院, 助教 (80403260) ; Kohmura Eiji 神戸大学, 医学(系)研究科(研究院), 教授 (30225388)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: microbeam x=ray / functional disease / neuronal disorders / selective neuronal death

Outline of Final Research Achievements

Coplanar micro mili meter beam X-ray irradiation on the central nervous system demonstrated that selective lesioning of neuronal pathway can be made while anatomical structures were maintained. This application is quite unique, in contrast to conventional stereotactic radiation therapy causing tissue necrosis. It enables that specific blockade of excitatory pathway and preservation of normal neuronal function in the surrounding area. It is also applicable repeatedly. Clinical applications for the treatment of drug-resistant epilepsy and advanced Parkinson disease are expected in the future.

Free Research Field

脳神経外科