Development of novel therapeutic methods by mesenchymal stem cells targeting glioma initiating cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462272
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kumamoto University
• Principal Investigator: Shinojima Naoki 熊本大学, 医学部附属病院, 寄附講座教員 (50648269)
• Research Collaborator: Lang Frederick F. Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Professor ; Tasaki Masayoshi 熊本大学, 大学院生命科学研究部保健学系構造機能解析学, 助教 ; Ando Yukio 熊本大学, 大学院生命科学研究部・神経内科学, 教授 ; Ichimura Koichi 国立がん研究センター研究所, 脳腫瘍連携研究分野, 分野長 ; Mikami Yoshiki 熊本大学, 医学部附属病院・病理診断科, 教授 ; Takakura Nobuyuki 大阪大学, 微生物病研究所・情報伝達分野, 教授 ; Era Takumi 熊本大学, 発生医学研究所幹細胞部門・幹細胞誘導分野, 教授 ; Yamada Kazumichi 熊本大学, 医学部附属病院・脳神経外科・機能神経外科先端医療寄付講座, 特任教授
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: グリオーマ幹細胞 / 腫瘍関連間質細胞 / CD44 / 再発・再増大 / Niches

Outline of Final Research Achievements

Glioblastoma, a representative of malignant gliomas, is a lethal tumor with a median survival time of about 15 months. As one of the mechanisms of the resistance to the treatment, it is suggested that glioma initiating cells (GICs) exist in the quiescent state by exiting from growth and division cycles and remaining in G0 state. Radiation and chemotherapy are able to kill regular tumor cells existing in growth and division cycles, but not GICs existing in the quiescent state, resulting in survival of GICs. Thus GICs enter into the growth and division cycle from G0 state by some cues, proliferate, and as a result they will recur. In this study, we found that CD44+ cancer associated stromal cells may be involved in the regulation of GICs' proliferation as the niches. It has been suggested that control of the CD44+ stromal cells leads to the control of recurrence.

Free Research Field

脳腫瘍