2016 Fiscal Year Final Research Report
Mechanism of the suppression of disc degeneration and innervation by prostanoid in human intervetebral disc cells.
Project/Area Number |
25462312
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Tokyo Medical University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 椎間板性腰痛 / 椎間板変性 / 神経侵入 / プロスタノイド |
Outline of Final Research Achievements |
The molecular mechanism of developing low back pain is known as disc degeneration by MMP and following nerve innervation by NGF. The effect of selective COX-2 inhibitors, which is clinically used for the conservative treatment of low back pain, on NGF and MMP expression was investigated in human lumbar intervertebral disc (IVD) cells. IL-1-induced NGF and MMP expressions were enhanced by selective COX-2 inhibitors, on the other hand, these expressions were suppressed by PGE2, PGE1 and its derivative limaprost via EP4 receptor. Our findings would be of importance when choosing drugs for the conservative treatment of low back pain.
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Free Research Field |
脊椎脊髄外科
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