Identification and characterization of tumorigenic stem cells in epithelioid sarcoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Fukuoka University
• Principal Investigator: NISHIO Jun 福岡大学, 医学部, 講師 (90360304)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 類上皮肉腫 / 腫瘍幹細胞 / 軟部腫瘍 / 染色体異常 / 脂肪肉腫

Outline of Final Research Achievements

Epithelioid sarcoma (EPS) is a highly malignant soft tissue tumor which is difficult to diagnose in some cases. EPS usually does not respond well to chemotherapy or radiotherapy; therefore, a novel therapeutic option needs to be developed. We analyzed the characteristics of cancer stem-like cells/cancer-initiating cells in EPS cell lines (FU-EPS-1 and SFT-8606). We isolated a subpopulation of cancer stem-like cells in the FU-EPS-1 cell line. In addition, we found that high-molecular weight glycoprotein CA125 would be a useful marker for monitoring the clinical course of EPS. Furthermore, we identified characteristic chromosomal aberrations in a variety of soft tissue tumors.

Free Research Field

外科系臨床医学・整形外科学