2015 Fiscal Year Final Research Report
Preventive measures against cognitive dysfunction following general anesthesia
Project/Area Number |
25462397
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology
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Research Institution | Akita University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KIMURA Tetsu 秋田大学, 医学(系)研究科(研究院), 講師 (00312702)
GOYAGI Toru 秋田大学, 医学部, 講師 (30302277)
HORIGUCHI Takashi 秋田大学, 医学部, 准教授 (70221570)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 認知機能障害 / 全身麻酔 / セボフルラン / キセノン / デクスメデトミジン / リチウム / アポトーシス |
Outline of Final Research Achievements |
The purpose of this study was to investigate the protective properties of dexmedetomidine, xenon, and lithium against cognitive dysfunction following sevoflurane anesthesia using aged rats. Although we used Morris water maze test to evaluate cognitive function, the function of aged rats could not be evaluated because their physical functions were severely impaired. Then, eight-arm radial maze test was used to evaluate cognitive function. However, it took months to train aged rats to determine baseline cognitive functions. Furthermore, the cognitive function was not altered by sevoflurane anesthesia though several combinations of sevoflurane concentration and duration were tested. Therefore, the protective properties of dexmedetomidine, xenon, or lithium against cognitive function were not investigated in this experimental period.
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Free Research Field |
麻酔蘇生学
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