The experiment to examine the effect of anesthetic agents on injured neurons

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462407
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Yokohama City University
• Principal Investigator: ANDOH Tomio 横浜市立大学, 医学(系)研究科(研究院), 客員教授 (00193110)
• Co-Investigator(Kenkyū-buntansha): KAMIYA Yoshinori 新潟大学, 医師学総合病院, 教授 (90381491)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 神経障害性疼痛

Outline of Final Research Achievements

The neuropathic pain model rats exhibit pain behaviour in 2 to 3 weeks after surgery. The phenomenon that down regulation of KCC2 and relative up regulation of NKCC1 has been proposed as promising mechanism underlying pain behaviour. We examined two models, SNL and CCI. While SNL rats did not exhibit the down regulation of KCC2, CCI showed the down regulation of pKCC2 in spinal dorsal horn, which is consistent with pain behaviour examined with weight distribution test. However the administration of CLP290, KCC2 activator, did not rescue pain behaviour.

Free Research Field

麻酔科学