Spinal cord protection by the activation of neuroglobin

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Yamaguchi University
• Principal Investigator: MATSUMOTO Mishiya 山口大学, 医学(系)研究科(研究院), 教授 (60243664)
• Co-Investigator(Kenkyū-buntansha): MIZUKAMI Yoichi 山口大学, 大学研究推進機構, 教授 (80274158) ; ISHIDA Kazuyoshi 山口大学, 大学院医学系研究科, 准教授 (80314813) ; WAKAMATSU Hiroya 山口大学, 医学部附属病院, 准教授 (80379966)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脊髄虚血 / ニューログロビン / 虚血耐性

Outline of Final Research Achievements

One of the devastating complications after thoracoabdominal aortic surgery is paraplegia. Paraplegia is thought to be a result of spinal cord ischemia during aortic occlusion. To protect against ischemic spinal cord injury, many drugs have been tested in animal experiments. However, no drugs have been established as being protective in the clinical setting. In this study, we examined neuroprotective effects of the activation of neuroglobin on the neurologic and histopathologic outcome after transient spinal cord ischemia in rabbits. Our results suggest that valproic acid that is thought to activate neuroglobin does not protect against ischemic spinal cord injury in rabbits.

Free Research Field

麻酔科学