2015 Fiscal Year Final Research Report
The restoring effect of anesthetics on damaged-endothelial glycocalyx
| Project/Area Number |
25462444
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
Edanaga Mitsutaka 札幌医科大学, 医学部, 講師 (70616169)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | グリコカリックス / 麻酔薬 |
|---|
| Outline of Final Research Achievements |
The healthy vascular endothelium is coated by endothelial glucocalyx that has several functions including an inert barrier, active reservoir, and mechanotransduction. From the viewpoint of preserve endothelial glycocalyx, the effect of anesthetics on endothelium-dependent vasodilation remains unclear. This study investigated the effect of anesthetics on endothelium-dependent vasodilation when endothelial glycocalyx damaged.
Endothelium-dependent vasodilation was significantly inhibited by sialidase which digests glycocalyx component. Sevoflurane restored this inhibition of endothelium-dependent vasodilation significantly.
|
| Free Research Field |
麻酔科学
|
