2016 Fiscal Year Final Research Report
Effect of endogenous NOS inhibitor on pulmonary arterial pressure
| Project/Area Number |
25462447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
|
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| Research Institution | Yokohama City University |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 肺高血圧 / 一酸化窒素 / 内皮細胞 |
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| Outline of Final Research Achievements |
Impairment of endogenous release of nitric oxide (NO), which causes vascular vasodilation and inhibition of smooth muscle cell proliferation, is well known to play a critical role in developing pulmonary hypertension (PH). We explored the mechanism of impared ehdothelial function and eNOS activity in PH using monocrotaline-induced PH rats.
Increase in PRMT2 and decrease in DDAH1 and DDAH2 in the PH model were associated with increased ADMA contents and consequent impairment of NOS activity. These results may be potentially useful to lower ADMA level for therapeutic benefit.
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| Free Research Field |
麻酔
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