2016 Fiscal Year Final Research Report
Effect of decreasing swelling by CRPS drug in animal model
| Project/Area Number |
25462452
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | International University of Health and Welfare (2015-2016)
Keio University (2013) |
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Principal Investigator |
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| Research Collaborator |
YAMABE Eiko
ABE Koji
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 慢性疼痛 / 末梢浮腫 / 拡散強調現象 / 磁気共鳴現象 / 慢性疼痛治療薬 / 異痛 / 神経損傷 |
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| Outline of Final Research Achievements |
We analyzed effect of Neurotropin, pregabalin and lidocaine in decrease of ADC and T2s of target organ in diffuion MR spectroscopy in chronic pain animal model (Chang model) to examine decrease of swelling. Changes of allodynia of lower extremity was also examined in the same animals. Allodynia increased 1 day after ligation of the L4 nerve root. Neurotropin decreased allodynia well while pregabalin and lidocaine had not changed allodynia. ADC and T2s had not changed with drugs application. Real-time PCR indicated no changes on TGF-a while decreased in VEGF that can suggest vascular disorder in lower extremity in chronic pain syndrome. Vascular conduction may be effective in edema of CRPS patients.
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| Free Research Field |
整形外科学
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