2015 Fiscal Year Final Research Report
Involvement of the transcription factor HIF-1 in the cell-to-cell adhesion system
| Project/Area Number |
25462457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Kiichi 関西医科大学, 医学部, 准教授 (00283606)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 周術期管理 / 低酸素 / 炎症 / HIF-1 / 細胞間バリア |
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| Outline of Final Research Achievements |
The respiratory epithelium forms an important barrier against inhaled pollutants and microorganisms, and its barrier function is often compromised during hypoxic insults. Epithelial activation of hypoxia- inducible factor-1 (HIF-1) represents one feature of airway inflammation, but the functional importance of HIF-1 within the respiratory epithelium is largely unknown. We evaluated the impact of HIF-1 activation on loss of epithelial barrier function during hypoxic insults.
Using several types of cell lines, we confirmed that expression of various adhesion molecules were modulated under hypoxic conditions in an HIF-1-dependent manner and that a critical involvement of HIF-1 in dysregulation of epithelial barrier function during hypoxic and inflammatory insults.
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| Free Research Field |
麻酔科学
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