2015 Fiscal Year Final Research Report
Effect of microenvironment on progression of CRPC and on docetaxel-resistance
| Project/Area Number |
25462473
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIZOKAMI Atsushi 金沢大学, 医学系, 准教授 (50248580)
KITAGAWA Yasuhide 金沢大学, 大学病院, 講師 (00452102)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 前立腺癌 / カバジタキセル耐性株 / 間質細胞 / 微小環境 |
|---|
| Outline of Final Research Achievements |
Although chemotherapy using docetaxel is conducted for castration-resistant prostate cancer (CRPC) after androgen-deprivation therapy, CRPC become resistant for docetaxel again. We hypothesized that the mechanism is related with tumor microenvironment. Then we co-cultured androgen-independent prostate cancer PC-3 with cancer-associated fibroblast (CAF) and investigated whether CAF affect docetaxel-sensitivity. However, CAF did not affect DOC-sensitivity.
Next, we hypothesized that CAF derived from CRPC is different from CAF from androgen-naive prostate cancer. Then we made gene expression profiles from CAF derived from CRPC and CAF from androgen-naive prostate cancer. We identified several differentially expressed genes. Now we are confirming whether these genes are related with CRPC progression.
|
| Free Research Field |
腫瘍学
|
