Inhibitory effects of carbonic anhydrase 2 inhibitor on the invasion of urinary bladder cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462499
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Osaka City University
• Principal Investigator: GI Min 大阪市立大学, 大学院医学研究科, 准教授 (70336783)
• Co-Investigator(Kenkyū-buntansha): TAMADA Satoshi 大阪市立大学, 大学院医学研究科, 講師 (20382179)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膀胱癌 / 炭酸脱水酵素２阻害薬

Outline of Final Research Achievements

We have demonstrated that that carbonic anhydrase 2 (CA2) is an invasion-associated factor in urothelial carcinoma (UC). The purpose to the present study is to examine the inhibitory effects of CA inhibitor Acetazolamide (Ace) on the N-butyl-N-(hydroxybutyl)nitrosameine (BBN)-induced mouse urinary bladder carcinogenesis. We found that concurrent treatment with Ace and Cisplatin (Cis) significantly inhibited the development of BBN-induced UC. Moreover, muscle invasive UC were significantly decreased by the Ace alone and concurrent treatment with Ace and Cis. These findings indicate that CA could serve as a potential therapeutic molecular target for bladder cancers and suggest that CA inhibitors are useful for prevention of UC invasion.

Free Research Field

実験病理学