Identification of the function of legumain in prostate cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462501
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Tokyo Medical University
• Principal Investigator: Ohno Yoshio 東京医科大学, 医学部, 准教授 (40266482)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 前立腺がん / レグメイン / 浸潤 / 低酸素

Outline of Final Research Achievements

Legumain is highly expressed in prostate cancer and other solid tumors and is a potential anticancer target. Here we investigated the role of legumain in invasion and metastasis in prostate cancer cell lines. In vitro invasion assay did not show significant difference in invasive ability regardless of legumain expression level.　In addition, hypoxic condition did not change legumain mRNA expression in prostate cancer cells. Therefore, we need experiment under chronic hypoxic condition and established hypoxia resistant prostate cancer cell line by continuous cultivation over 6 months. Legumain expression on mRNA level in hypoxia resistant cell lines was higher than that in parental cell lines. We have a plan of further study.

Free Research Field

泌尿器科癌