The role of sensory neuron-specific receptor in the regulation of micturition reflex

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462513
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Tottori University
• Principal Investigator: HONDA Masashi 鳥取大学, 医学部附属病院, 講師 (20362890)
• Co-Investigator(Kenkyū-buntansha): TAKENAKA Atsushi 鳥取大学, 医学部, 教授 (50368669) ; SAITO Motoaki 高知大学, 医歯学系, 教授 (60273893)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 下部尿路機能障害 / 新規受容体 / SNSR / シクロホスファミド誘発膀胱炎 / 膀胱内圧測定

Outline of Final Research Achievements

A novel family of G-protein-coupled receptors has been identified in rat dorsal root ganglia and named as sensory neuron-specific receptors (SNSRs). Intravenous or intrathecal administration of BAM8-22, a selective rat SNSR1 agonist, can suppress cyclophosphamide-induced bladder overactivity, probably due to suppression of bladder afferent activity. In urethane-anesthetized rats, intravesical administration of BAM8-22 can ameliorate cyclophosphamide-induced bladder overactivity via suppression of capsaicin sensitive C-fiber afferent pathways in rats. Thus, SNSRs could be an effective target for the treatment of bladder dysfunction such as overactive bladder and bladder pain syndrome/interstitial cystitis, for which C-fiber afferent hyperexcitability has been proposed to be an important pathophysiological basis.

Free Research Field

神経泌尿器科