Investigation for the role of GDNF in benign prostate hyperplasia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462522
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Takada Masa 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (60468254)
• Co-Investigator(Kenkyū-buntansha): KUBOTA Yasue 名古屋市立大学, 大学院医学研究科, 講師 (00381830) ; IMURA Makoto 名古屋市立大学, 大学院医学研究科, 研究員 (00551269) ; SHIBATA Yasuhiro 名古屋市立大学, 大学院医学研究科, 助教 (10534745) ; KOHRI Kenjiro 名古屋市立大学, 学長 (30122047) ; SASAKI Shoichi 名古屋市立大学, 大学院医学研究科, 准教授 (50225869) ; KOJIMA Yoshiyuki 福島県立医科大学, 医学部, 教授 (60305539)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 前立腺肥大症 / 泌尿器科学 / GDNF

Outline of Final Research Achievements

Benign prostate hyperplasia is a non-cancerous enlargement of the prostate which cause lower urinary tract symptoms, such as urinary frequency, urinary urgency interrupted urine stream and so on. Aging society increase the BPH　prevalence and these symptoms degrade the quality of life. Although BPH is common, the cause of BPH is still unclear.
To investigate the mechanism of BPH development, we use the novel BPH model which was made by implanting the urogenital sinus of neonatal rats to sub-capsule of the prostate of adult male rats. 　Using this model we discovered the grail-cell derived neurotrophic factor (GDNF) plays the important role in interstitial cell proliferation.
In this study, we demonstrate the GDNF increase the growth rate of human prostate interstitial cell line, and in these cell line signal cascade such as RET phosphorylation pathway and GZF1 were activated.

Free Research Field

泌尿器科学