2015 Fiscal Year Final Research Report
A new therapy for blood purification of oxidative stress and uremic toxin verified by mouse kidney transplantation
| Project/Area Number |
25462533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tohoku University |
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Principal Investigator |
Abe Michiaki 東北大学, 大学病院, 准教授 (40400246)
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| Research Collaborator |
OKUDA HIROSHI 東北メディカル・メガバンク機構, 大学院生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 血液浄化 / 尿毒症性物質 / 腎移植実験 / 慢性腎臓病 |
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| Outline of Final Research Achievements |
The project including a mouse kidney transplantation was extremely so difficult to accomplish in Japan that our graduate student studied abroad and carry forward the experiment in Duke University Medical Center, kidney research institute (Prof. Coffman TM) one and a half years ago. The donor mouse kidney, the size as same as adzuki bean, is quickly transplanted to a recipient mouse under an ophthalmologic microscope in 11-0 suture without injuring the renal artery, vein and ureter. This project has been going still now.
The final aim of this project is development of a new therapeutic agent for chronic kidney disease by blood purification of uremic material and oxidation stress. As the new candidate drug was found, I started a cohort study of it.
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| Free Research Field |
腎機能
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