2015 Fiscal Year Final Research Report
Comprehensive gene expression analysis of neonatal ischemic-hypoxic encephalopathy animal model at acute phase
Project/Area Number |
25462553
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Toyohashi University of Technology |
Principal Investigator |
Kojima Toshio 豊橋技術科学大学, 健康支援センター, 教授 (00311340)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 低酸素性虚血性脳症 / 網羅的遺伝子発現解析 |
Outline of Final Research Achievements |
In this study, we performed comprehensive gene expression analysis of the contra-lesional cerebrum of neonatal ischemic-hypoxic encephalopathy animal model at acute phase. The results suggest that 1 hour after lesioning, inflammatory responses are induced, and that induced inflammatory reactions continue at 24 hour after lesioning. Furthermore, neuropathy progression is suggested at both 1 hour and 24 hour after lesioning. From these results, we concluded that the contra-lesional hemisphere of neonatal ischemic-hypoxic encephalopathy animal model is important subject of investigation.
|
Free Research Field |
ゲノム医科学
|