Fetal heart rate responses to intra-amniotic endotoxin in chronically instrumented fetal sheep

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462569
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Fukushima Medical University
• Principal Investigator: FUJIMORI Keiya 福島県立医科大学, 医学部, 教授 (80285030)
• Co-Investigator(Kenkyū-buntansha): KYOZUKA Hyo 福島県立医科大学, 医学部, 助手 (00644113) ; YASUDA Shun 福島県立医科大学, 医学部, 助手 (50566817) ; NOMURA Yasuhisa 福島県立医科大学, 医学部, 講師 (60381381) ; KAWAMURA Makoto 福島県立医科大学, 医学部, 助手 (10713133)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 羊胎仔 / 絨毛膜羊膜炎 / 高サイトカイン血症 / 胎児心拍数 / 心拍数基線細変動 / 圧受容体反射

Outline of Final Research Achievements

The purpose of this study was to investigate the effects of intra-amniotic endotoxin on fetal heart rate (FHR) in chronically instrumented fetal sheep.　Granulocyte-colony stimulating factor was injected intravenously to the fetuses for 4 days after the postoperative second day. The 40mg of lipopolysaccharide (LPS) was also infused in the amniotic cavity for 2 days after the postoperative 4th day.
The number of FHR acceleration, and short term variability (STV) and long term variability (LTV) of FHR, were evaluated for 24 hours after the first injection of LPS. The effect of intra-amniotic LPS on baroreflex sensitivity was also examined during phenylephrine injections to the fetus. The FHR was significantly increased throughout the 24 hours from the beginning of LPS injection. The FHR accelerations, STV, and LTV were significantly decreased after 18 hours of the LPS administrations. The baroreflex sensitivity was significantly decreased after LPS injection.

Free Research Field

産科学