Establishment of polymer-equipped oncolytic virotherapeutics against ovarian cancer.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462597
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nagoya University (2015); Ehime University (2013)
• Principal Investigator: NAWA Akihiro 名古屋大学, 医学(系)研究科(研究院), 特任教授 (90242859)
• Co-Investigator(Kenkyū-buntansha): YASUKAWA Masaki 愛媛大学, 大学院医学研究科, 教授 (60127917)
• Research Collaborator: MUTO Yoshifumi 名古屋大学, 大学院医学系研究科, 客員研究員 ; KOYA Yoshihiro 名古屋大学, 大学院医学系研究科, 客員研究員
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腫瘍溶解性ウイルス / 卵巣癌腹膜播種 / ナノポリマー修飾 / HF10 / 葉酸レセプター / FOLR1 / 腹膜播種モデルマウス

Outline of Final Research Achievements

Ovarian cancer is the leading cause of death among women with gynecologic malignancies. Herpesvirus strain HF10 has promising oncolytic activity against a variety of tumor cells and xenografts. In this study, we established a novel virus delivery system targeting to folate receptor alpha molecules, highly expressed among 90% of ovarian cancer cells, and its in vitro evaluation system. The delivery system made it possible that oncolytic virus specifically killed ovarian cancer cells through viral lytic infection. We developed also an in vivo evaluation system using syngenic graft model of ovarian cancer, harboring immunocompetence, for various types of oncolytic virotherapeutics. It enabled to assess the host immune responses against the oncolytic virus infection.

Free Research Field

婦人科腫瘍学