2015 Fiscal Year Final Research Report
Biological characteristics of endometrial cancer with lifestyle-related diseases.
| Project/Area Number |
25462609
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 子宮体癌 / 脂質異常症 / がん代謝 / QOL / ドラッグリポジショニング / 女性ヘルスケア |
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| Outline of Final Research Achievements |
This study aimed to reveal relationship between environmental factors and genetic factors in endometrial cancer survivors. We recruited clinical informations and samples from menopause clinic, Keio University Hospital, Tokyo, Japan. Our results revealed 1)Hypertriglyceridemia was statistically more frequent in patients who had undergone bilateral salpingo-oophorectomy both before and after menopause than in the corresponding non-endometrial cancer controls, 2) Osteoporosis was associated with hypertriglyceridemia in post-menopausal women without endometrial cancer, but was less frequent in endometrial cancer survivors with hypertriglyceridemia, and 3) No significant association was found between osteoporosis and polymorphisms in ESR1, UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more significant physiological factor in influencing bone mass density compared to genetic variations.
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| Free Research Field |
婦人科腫瘍学
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