Investigation of the role of glycolipids in anticancer drug resistance of ovarian carcinoma derived cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462610
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: tanaka kyoko 慶應義塾大学, 医学部, 講師 (10286536)
• Co-Investigator(Kenkyū-buntansha): IWAMORI Masao 近畿大学, 理工学部, 講師 (90110022)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 硫酸化糖脂質 / 子宮内膜癌 / 高分化・低分化型 / 粘液性卵巣癌 / 抗がん剤感受性 / 抗がん剤耐性 / 遺伝子導入

Outline of Final Research Achievements

We determine the glycolipid　expressions in endometrial carcinoma and ovarian carcinoma　tissues. Sulfatide did not expressed in endometrial carcinoma in poorly differentiated type, but it expressed in well-differentiated type. Ovarian mucinous adenocarcinoma tissues preferentially contained　sulfatide which was more than 5 times of high concentration of well-differentiated endometrial carcinoma. Sulfotransferase gene was transfected in SNG-II cells, which did not contain sulfated glycolipid. The transfected cells revealed more resistant properties toward anticancer drugs than SNG-II cells. It indicated that Sulfatide is concerned with sensitivity or resistance in an anticancer drugs.

Free Research Field

産婦人科