2015 Fiscal Year Final Research Report
Investigation for the mechanism of human and animal cochlea dysfunction of PMP22 gene
| Project/Area Number |
25462630
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA KEN 東京医科歯科大学, 大学院医歯学総合研究科, 特任教授 (90010470)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 内耳 |
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| Outline of Final Research Achievements |
Charcot-Marie-Tooth disease causes the sensorineural hearing loss regarded as cochlea dysfunction. We investigated the isolation and molecular mechanism of the PMP gene in the inner ear and cochlear dysfunction in order to figure out the mechanism of the sensorineural hearing loss for Charcot-Marie-Tooth disease . The portion close to the outer hair cells of the animal models demonstrated intense immunohistochemical reaction by the anti-pmp antibody using confocal laser scanning microscopy and frozen section. However, we could not identify the specification of localization in the organ of Corti and the cause of hearing loss. We need to accumulate the data for analysis. We are also analyzing the data about the localization of pmp22 protein in the human cochlea.
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| Free Research Field |
耳科学
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