Molecuar mechanisms and new therapeutic strategies for tinnitus

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462639
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nara Medical University (2015); Osaka University (2013)
• Principal Investigator: Kitahara Tadashi 奈良県立医科大学, 医学部, 教授 (30343255)
• Co-Investigator(Kenkyū-buntansha): IMAI TAKAO 大阪大学, 医学(系)研究科(研究院), 講師 (80570663) ; OTA YUMI 大阪大学, 医学(系)研究科(研究院), 助教 (00598401) ; MORIHANA TETSUO 大阪大学, 医学(系)研究科(研究院), 助教 (80634170)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 耳鳴 / 逃避行動 / TRPファミリー / 侵害受容体 / サリチル酸 / 動物モデル

Outline of Final Research Achievements

Due to moving from Osaka University to Nara Medical University, we established the animal behavioral model for tinnitus again. Salicylate-induced tinnitus in rats could be visualized by behavioral and molecular experiments. Behavioral experiments were performed using an active avoidance task and molecular experiments were performed using a nociceptive receptor, transient receptor potential cation channel superfamily V (TRPV) in the rat auditory pathway. By means of these tinnitus visualization experiments, capsazepine, a specific antagonist of TRPV1, could be one of candidates to block tinnitus pathway and cure tinnitus. Further additional experiments are required.

Free Research Field

耳科・神経耳科