Role of inflammasome and Toll-like receptor in chronic otitis media

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462642
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Okayama University
• Principal Investigator: Kariya Shin 岡山大学, 大学病院, 講師 (10274226)
• Research Collaborator: ISHIHARA Hisashi ; ZHAO Pengfei
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 中耳炎 / サイトカイン / 炎症 / 感染症

Outline of Final Research Achievements

Cholesteatoma is a destructive disease consisting of keratinizing squamous epithelium in the middle ear. Cholesteatoma is accompanied by a chronic inflammatory reaction resulting in the destruction of epithelial and bony structures of the middle ear. Chronic otitis media is a persistent inflammation or infection of the middle ear. However, the pathogenic mechanisms of cholesteatoma and chronic otitis media have not been fully understood. This study sought to assess the expression of NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in middle ear tissues in patients with cholesteatoma or chronic otitis media. Our findings suggest that NLRP3 inflammasome plays an important role in the pathogenesis of middle ear diseases. Modulation of inflammasome-mediated inflammation may be a novel therapeutic strategy for cholesteatoma and chronic otitis media

Free Research Field

耳鼻咽喉科・頭頸部外科