HSV amplicon vector to treat facial nerve palsy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462650
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nagoya City University
• Principal Investigator: Murakami Shingo 名古屋市立大学, 医学(系)研究科(研究院), 教授 (80157750)
• Co-Investigator(Kenkyū-buntansha): Hida Hideki 名古屋市立大学, 医学研究科, 教授 (00305525) ; Hamajima Yuki 名古屋市立大学, 医学研究科, 講師 (30343403) ; Esaki Shinichi 名古屋市立大学, 医学研究科, 助教 (20620983)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 顔面神経麻痺 / 単純ヘルペスウイルス / アンプリコンベクター

Outline of Final Research Achievements

Bell’s palsy is highly associated with diabetes mellitus (DM). Diabetes mellitus was induced with streptozotocin injection in only mice that developed transient facial nerve paralysis with HSV-1. Recurrent facial palsy was induced after HSV-1 reactivation by auricular scratch. After DM induction, the number of CD3+ T cells decreased by 70% in the DM mice, and facial nerve palsy recurred in 13% of the DM mice. HSV-1 DNA was detected in the facial nerve of all of the DM mice with palsy, and HSV-1 capsids were found in the geniculate ganglion using electron microscopy. These results suggested that HSV-1 reactivation in the geniculate ganglion may be the main causative factor of the increased incidence of facial paralysis in DM patients.

Free Research Field

顔面神経麻痺