2015 Fiscal Year Final Research Report
Role of mast cell in the development of eosinophilic chronic rhinosinusitis
| Project/Area Number |
25462660
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 好酸球性副鼻腔炎 / 肥満細胞 / 好酸球 / Tryptase / Chymase / 線維化 / 創傷治癒 |
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| Outline of Final Research Achievements |
In this study, we evaluated the role of mast cell in the development of eosinophilic chronic rhinosinusitis (ECRS). We reported that the number of mast cell infiltrated in epithelium of ECRS were significantly increased compared to control tissue. Furthermore, expression pattern of mast cell intrinsic proteases were different from previously reported type. This changes were confirmed by using primary cultured mast cell stimulated by cytokines from airway epithelial cell. We concluded that this type of mast cells were involved in the development of the ECRS pathogenesis.
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| Free Research Field |
上気道免疫
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