Involvement of Sulfated Gycosaminoglycan in the Pathogenesis of Diabetic Retinopathy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462701
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: YOSHIZAWA Chikako 北海道大学, 医学(系)研究科(研究院), 客員研究員 (80533653)
• Co-Investigator(Kenkyū-buntansha): SUGAWARA Kazuyuki 北海道大学, 先端生命科学研究科, 名誉教授 (60154449) ; KANDA Atsuhiro 北海道大学, 大学院医学研究科, 特任講師 (80342707)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 硫酸化グリコサミノグリカン / 糖尿病網膜症 / 糖鎖

Outline of Final Research Achievements

The white blood cells were purified from diabetes-induced mouse model, and analyzed composition of sulfated glycosaminoglycan. However, compared to control mice, significant difference was not observed. Therefore, we comprehensively analyzed sugar chains in the vitreous fluids from diabetic retinopathy patients. As results, total glycan amount including sulfated glycosaminoglycan were significantly elevated in diabetic retinopathy patients than in non-diabetic patients (control group). This suggests that increased glycans may be involved in the pathogenesis of diabetic retinopathy.

Free Research Field

眼科学