Analysis of Lamina Cribrosa Structure and Genome in Glaucomatous Eyes and Development of Therapy Evaluation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462713
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: AKAGI TADAMICHI 京都大学, 医学(系)研究科(研究院), 講師 (30580112)
• Co-Investigator(Kenkyū-buntansha): GOTO Morimoto 京都大学, 医学研究科, 准教授 (20632095) ; IKEDA Hanako 京都大学, 医学研究科, 准教授 (20372162)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 緑内障 / 眼圧下降 / 篩状板 / 強度近視 / 遺伝子

Outline of Final Research Achievements

The change in lamina cribrosa (LC) depth after intraocular pressure (IOP) reduction was confirmed. It was associated with IOP change, age, severity of glaucomatous optic neuropathy, and baseline LC depth. We further found that some eyes with high myopia and high IOP could change their eyeball shape as a response to IOP reduction. Deformed eyeball shape might be affected by high IOP and IOP reduction might reduce scleral deformation in highly myopic eyes with high IOP. We could not detect a significant association between rs4977756 of CDKN2B-AS1 and POAG in a Japanese cohort with high myopia, which suggests that the odds ratio of developing POAG for rs4977756 would not exceed 1.70.

Free Research Field

眼科学