Strategy of photoreceptor protective treatment for retinitis pigmentosa

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462746
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hirosaki University
• Principal Investigator: Metoki Tomomi 弘前大学, 医学部附属病院, 講師 (00400169)
• Co-Investigator(Renkei-kenkyūsha): Nakazawa Mitsuru 弘前大学, 大学院医学研究科, 教授 (80180272)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 眼科学 / 網膜色素変性 / カルパイン / 眼薬理学

Outline of Final Research Achievements

We previously reported that the 10-amino-acid fragment derived from the large fragment of rat mitochondrial calpain-1 have an inhibitory effect on the mitochondrial calpain-1. In the present study, we clarified that this peptide can be delivered to the rabbit retina by a topical instillation. In addition, we successfully made iPS cells from human skin fibroblasts for our future research projects. We also studied to examine whether or not the peptide derived from rats can demonstrate protective effects on human-derived cells such as ARPE-19 cells.

Free Research Field

眼科学