Development of new glaucoma therapy other than decreasing intraocular pressure

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462750
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Akita University
• Principal Investigator: Yoshitomi Takeshi 秋田大学, 医学(系)研究科(研究院), 教授 (60191623)
• Co-Investigator(Kenkyū-buntansha): ISHIKAWA Makoto 秋田大学, 大学院医学系研究科, 准教授 (10212854)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 緑内障 / 眼循環 / 血管平滑筋 / 薬理学

Outline of Final Research Achievements

Topically applied carbonic anhydrase inhibitor can increase optic disc blood flow in rabbit which was assessed using laser speckle flowgraphy analyzer. Further, we investigate the direct pharmacological effect of acetazolamide and dorzolamide on isolated ciliary arterial smooth muscle. Acetazolamide had little effect compared with dorzolamide on isolated rabbit ciliary arteries in vitro using isometric tension recording method. Those results indicate that carbonic unhydrase inhibitor increase optic nerve blood flow with different pharmacological mechanisms from decreasing intraocular pressure Jpn J Ophthalmol. 2016;60:103-10）.

Free Research Field

眼科　緑内障