2016 Fiscal Year Final Research Report
Elucidation of viral keratitis pathogenesis by comprehensive molecular analyses
| Project/Area Number |
25462755
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Research Collaborator |
HARUKI Tomoko
KANDORI Michiko
SASAKI Shin-ichi
OHTANI Fumie
UOTANI Ryu
SHIMIZU Daisuke
YAKURA Keiko
SHIMIZU Yumiko
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 単純ヘルペスウイルス / サイトメガロウイルス / 角膜内皮 / マイクロアレイ / IDO / 制御性T細胞 / IRF7 / RAGE |
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| Outline of Final Research Achievements |
Molecules were comprehensively analyzed in corneal endothelial cells infected with herpes simplex virus (HSV) and cytomegalovirus in vitro by microarray technique, and these analyses indicated the importance of molecules related with interferon signaling, pattern recognition receptors, and antigen presentation.
Especially, indoleamine 2,3-dioxygenase (IDO）induced HSV antigen-specific regulatory T cells, and resulted in immune tolerance. Also interferon regulatory factor 7(IRF7) induced both innate and acquired immunity, and receptors for advanced glycation endproducts (RAGE) were related with the induction of interferon-β after HSV infection.
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| Free Research Field |
医学/眼科学/角膜・眼感染症
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