The wound healing system applied new antibiotic agent Firmocidin and eccrine sweat natural immunity

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462795
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Ehime University
• Principal Investigator: Nakaoka Hiroki 愛媛大学, 医学部附属病院, 准教授 (30172266)
• Co-Investigator(Kenkyū-buntansha): Murakami Masamoto 愛媛大学, 医学部附属病院, 講師 (20278302)
• Co-Investigator(Renkei-kenkyūsha): Shirakata Yuju 愛媛大学, 医学部附属病院, 准教授 (50226320)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 創傷治癒 / 自然免疫 / エックリン汗

Outline of Final Research Achievements

In a wound model of two-dimensional keratinocyte culture system and LSE, it was difficult to reproduce the bacterial infection model in the wound only with bacteria, keratinocyte, and antibacterial agents. The examination about the wound healing delay using the CRAMP knockout mise in vivo could not run, because continuous supply of Firmocidin from the colleague had been impossible. In vivo examination results may lead to the identification of desired cells. We wait for Firmocidin supply and are going to develop further examination continuously.

Free Research Field

形成外科