2015 Fiscal Year Final Research Report
The role of the serum-derived Nanopaticle in the diabetic wound healing disorders
| Project/Area Number |
25462808
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKIBUCHI Masao 兵庫医科大学, 医学部, 教授 (50252664)
NISHIMOTO Soh 兵庫医科大学, 医学部, 教授 (30281124)
ISHISE Hisako 兵庫医科大学, 医学部, 病院助手 (30567194)
FUJITA Kazutoshi 兵庫医科大学, 医学部, 助教 (40461066)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 創傷治癒 / 機械的刺激 / TRPC3 |
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| Outline of Final Research Achievements |
Initially, we tried to investigate how Adiponectin, which is known to be decreased in diabetic condition, acts on the local Ca2+ homeostasis in the wounds through Serum-derived Nanoparticle formation/degradation. However, it was so difficult to synthesize Adiponectin protein that we started to study about ion channels in the wound simultaneously.
Among Transient Receptor Potential cation channels, TRPC3 was appeared to be up-regulated in the hypertrophic scar contracture tissue. When cyclic stretch stimuli were applied to the cutaneous fibroblasts, the expression of TRPC3 was elevated. Furthermore, in the TRPC3 overexpressing fibroblasts, cyclic stretch stimuli raised cytoplasm Ca2+ concentration , which lead to the phosphorylation of NFκB and the up-regulation of FIbronectin.
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| Free Research Field |
形成外科
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