2015 Fiscal Year Final Research Report
Blocking the interaction of coagulation and inflammation, and significance of vasoactive substances in DIC
| Project/Area Number |
25462818
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | DIC |
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| Outline of Final Research Achievements |
Disseminated intravascular coagulation (DIC) is a serious disease that, in the presence of underlying disease, causes persistent, generalized, marked coagulation activation. Early treatment based on an appropriate diagnosis is very important for improving patients’ prognosis.
The commonly used conventional animal models of DIC are induced with LPS or tissue factor (TF), and they have been considered to be essentially the same pathologically. However, our group recently showed that the pathology differs greatly depending on the DIC inducer used, at the view point of coagulofibrinolytic activation, inflammation and vasoactive substances.
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| Free Research Field |
血栓止血
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