Predictive value of serum NGAL for the neurological outcome of post cardiac arrest victims

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462824
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kumamoto University
• Principal Investigator: KASAOKA SHUNJI 熊本大学, 医学部附属病院, 教授 (90243667)
• Co-Investigator(Kenkyū-buntansha): FUJITA Motoki 山口大学, 大学院医学系研究科, 助教 (50380001)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 心停止後症候群 / バイオマーカー / 予後予測

Outline of Final Research Achievements

In this study, we measured serum NGAL in post cardiac arrest syndrome (PCAS) patients to investigate the predictive value of neurological outcome.
Serum NGAL showed significant difference in day 2 (G: 282±116 ng/mL v.s. P: 299±87 ng/mL in day1: P = 0.609, G: 185±124 ng/mL v.s. P: 353±110 ng/mL in day 2: P<0.001). The ROC curve analysis showed area under the curve of NGAL in day 2 was 0.871, and the area of NSE in day2 showed 0.918.
Serum NGAL in PCAS patients had the predictive value for neurological outcome which is comparable to serum NSE.

Free Research Field

救急医学