2015 Fiscal Year Final Research Report
Systematic study on brain circulation during anaphylactic shock
| Project/Area Number |
25462839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURATA Yasutaka 金沢医科大学, 医学部, 教授 (00267725)
TONAMI Hisao 金沢医科大学, 医学部, 教授 (70139773)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | brain circulation / anaphylactic shock / rat / autoregulation / brain blood flow / vascular permeability / brain MRI / edema |
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| Outline of Final Research Achievements |
The pathophysiology of brain circulation during anaphylactic shock remains unclear. By using the anaphylactic shock model in which an intravenous injection of the ovalbumin antigen caused systemic hypotension in anesthetized sensitized rats, we clarified the occurrence of 1) increased cerebral vascular permeability, 2) cerebral edema, and 3) cerebral blood flow autoregulation. We found that cerebral vascular permeability did not increase during anaphylactic hypotension, as evaluated by the Evans blue dye method. Brain edema did not develop when anaphylactic hypotension occurred, as evaluated by the magnetic resonance method and the brain water measurement. Finally, cerebral blood flow decreased in parallel with a decrease in blood pressure, indicating the absence of cerebral blood flow autoregulation. In conclusion, either increased brain vascular permeability, brain edema, or cerebral blood flow autoregulation is not observed during anaphylactic hypotension in anesthetized rats.
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| Free Research Field |
生理学
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