2016 Fiscal Year Final Research Report
Analysis of cisplatin resistance of PTP4A1 and identification of new endogenous resistance gene to cisplatin
| Project/Area Number |
25462912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
UEDA Michihiro 北海道がんセンター
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | シスプラチン耐性 |
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| Outline of Final Research Achievements |
We have explored cisplatin resistance genes to predict the efficacy of chemotherapy for oral cancer. In this experiments we established resistance and sensitive cell lines. Since PTP4A1 has been identified as resistance gene before by us, we analyzed PTP4A1 mRNA expression in both cell lines. But there was no difference between resistance and sensitive cell lines. We found JNK inhibitor caused cell death especially in resistance cell lines. JNK activity was more increased in resistance cell lines compared to sensitive. These results indicated JNK activity was related to cisplatin resistance and combination of cisplatin and JNK inhibitor can eliminate cancer tissue which have tolerance to cisplatin.
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| Free Research Field |
口腔病理学
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