2015 Fiscal Year Final Research Report
The role of the Mediator complexes in transcriptional regulation of the chemokine genes
| Project/Area Number |
25462928
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Hiroi Miki 明海大学, 歯学部, 講師 (30419717)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 転写制御 / ケモカイン / インターフェロン / メディエーター複合体 / CDK8 / STAT1 / CXCL9 / CXCL10 |
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| Outline of Final Research Achievements |
Inflammatory reactions and immune responses are regulated by a diverse array of extracellular stimuli such as cytokines in the tissue microenvironment. The purpose of this study is to elucidate the mechanisms how the extracellular stimuli induce the inflammatory genes including chemokines. Inflammatory cytokines TNFα and IFNγ synergistically induced the expression of chemokine CXCL9, CXCL10 genes and the Mediator complex, which functions to integrate transcriptional activators and RNA polymerase II, negatively regulated the chemokine gene expressions.
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| Free Research Field |
転写制御
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