Elucidate the mechanism of aggravation of endodontic disease on diabetic patients

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462960
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Uchida Yushi 広島大学, 医歯薬保健学研究院, 助教 (40363080)
• Co-Investigator(Kenkyū-buntansha): OUHARA Kazuhisa 広島大学, 大学院医歯薬保健学研究院, 助教 (80550425)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 糖尿病 / 歯内疾患 / 好中球

Outline of Final Research Achievements

Diabetes Mellitus (DM) effects on endodontic disease as other disease. Endodontic disease of DM model mouse proceeds more rapidly than normal mouse. The white blood cell which circulated through the whole body change the some functions, and the inflammation of endodontic tissue proceed rapidly. But the fibroblasts from pulp tissue on DM patients produce the receptor for advanced glycation endproducts (RAGE) as much as healthy subjects. It might be very important that RAGE on the white blood cell more than cell of endodontic tissue.

Free Research Field

歯内歯周病学